Correlation between the composition of PLA-based folate targeted micelles and release of phosphonate derivative of betulin

There are increasing numbers of developed nanocarriers for anticancer drug delivery in the aim to avoid side effects conventional chemotherapy. Filomicelles with folic acid (FA) as a targeting moiety novel approach that can potentially maximize therapeutic efficacy while minimizing effects. The this study was analyze influence composition PLA-based micelles functionalized on their encapsulation and release properties well cytotoxic activity against cancer cells. Micelles were obtained from combination poly (l-lactide)-Jeffamine-folic (PLA-Jeff-FA) (l-lactide)-poly (ethylene glycol) (PLA-PEG) or glycol)-folic PLA-PEG. E?29-diethoxyphosphoryl-28-O-propynoylbetulin an agent encapsulated into micelles. vitro biocompatibility drug-free confirmed cytotoxicity loaded FR-positive SK-BR-3 provided active over 260 h. However, characterized differences morphology, loading properties. hydrophobic block length has been identified factor may be used control inter- intramolecular interactions and, consequence, micelle's properties, e.g. efficiency rate.